Founded in 1986, the Information Systems Laboratory has become a major focal point in the international research community. It combines expertise in knowledge representation and reasoning, database systems, net-centric information systems, and conceptual modeling. Its grand research challenge is to succeed in the transition from traditional information systems, such as information retrieval systems, database and workflow management systems, to semantically rich, large-scale, adaptive information systems. Such systems will be characterized by large-scale semantic interoperation, massive distribution, and/or a high level of autonomy and self-adaptation.